process for the production of 4 - amino - 6,7dimethoxy - 2 - (4 - (euro 2 yl) - piperazine - 1-yl) and its physiologically acceptable salts chinazolin.

摘要

The invention relates to a new multistage process for the production of 4-amino-6,7-dimethoxy-2-[4-(furo-2-yl)-piperazin-1-yl]-quinazoline corresponding to the following formula IMAGE and physiologically compatible salts thereof, which gives better yields and uses less expensive and more reactive materials than known processes. The intermediate product formed in this process, N''-cyano-N'-(3,4-dimethoxyphenyl)-O-phenylisourea, shows antihypertensive activity on its own.