alpha chlorinated carbonates, their manufacturing process and their use for the protection of amingruppen in aminosaeuren.

摘要

The invention relates to new alpha -chlorinated carbonates characterized in that their formula is: IMAGE in which X is a fluorine, chlorine or bromine atom and R1 is different from the IMAGE group and represents; a substituted or non-substituted, saturated or unsaturated, aliphatic, araliphatic, primary, secondary, tertiary or cycloaliphatic radical. These alpha -chlorinated carbonates are prepared by the action of a compound of formula R1OH on a chloroformate of formula: IMAGE in a solvent medium in the presence of an acid scavenger which is added after the two preceding compounds. They are used to block the amine function of amino acids. The alpha -chlorinated carbonate and amino acid are reacted in a solvent medium at a temperature of -5 DEG to 100 DEG C. in the presence of an acid scavenger. Blocked amines are very useful in peptide synthesis.