substituted hexahydropyrrolo (1.2 (a) chinoline, hexahydro - 1h - pyrido (1,2 - (a) - (e) chinoline, hexahydrobenzo indene and octahydrophenanthrene as means with effects on the central nervous system.

摘要

Tricyclic benzo fused compounds of the formula IMAGE (I) and pharmaceutically acceptable cationic and acid addition salts thereof, wherein n is zero, 1 or 2, and t is 1 or 2; M is CH or N, R1 is H or certain acyl groups; Q is CO2R4, COR5, C(OR7)R5R6, CN, CONR9R10, CH2NR9R10, CH2NHCOR11, CH2NHSO2R12, 5-tetrazolyl or when n is 1, Q and OR1 together form a lactone or certain reduced derivatives thereof; and Z is certain alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl groups, are valuable central nervous system active agents, methods for their use, pharmaceutical compositions containing them and certain intermediates therefor.