A New procedure for Preparation of dipeptides with Inhibitory activity of renin.

摘要

Method for preparing novel dipeptides. Consists in reacting a compound of formula (ii) with a compound of formula (iii) in the presence of a sulfoxide, between c10jc and temperature for 30 min to 15 days, to obtain a compound of formula (i) and its pharmaceutically acceptable Salts.Being alquileno: C 1, C 2, 4 or alquileno 4; R1 and R2, alkyl C 10 or 1 - (P -) R3 R6; c, alkyl of 1 to 10; R4, Isopropyl or cycloalkyl C 3 to 8; R5, Hydroxy or alkoxy C 1 to 10; aryl or - B - R6, R7; (b) alquileno C 1 to 4; R7, alkoxy C 1 to 4; and - NH - CCH (R3) Co, M and P, 0 OR 1. G, and S 1. It is used to control hypertension high blood pressure.