Procedure for the preparation of new halogenated derivatives of the 16-alpha-methyl-pregnan series. (Machine-translation by Google Translate, not legally binding)

摘要

NEW HALOGENATED DERIVATIVES OF THE 16-ALPHA-METHYL-PREGNANE (I) SERIES ARE PREPARED, WHERE L IS HYDROGEN OR C1-C8 ACIL, LIKE PROPANOYL, ISONICOTINOYL, AND IS CHLORINE OR FLUORINE, AND X CHLORINE, SUBMITTING A COMPOUND (II) TO THE ACTION OF HALOGENATING AGENTS, FORMED BY THE MIXTURE OF NX-SUCCINIMIDE AND A DONOR OF HALOGENIDE AND RAISED TO -, AND SUBSEQUENTLY SAPONIFIED IN (I) TO BE HYDROGEN. DUE TO ITS LOCAL ANTI-INFLAMMATORY ACTIVITY AND ITS ABSENCE OF ANTI-INFLAMMATORY ACTIVITY, THE COMPOUND CAN BE USED IN HIGH DOSE WITHOUT HAVING THE SIDE EFFECTS OF CORTISONIC TYPE AND THEY ARE APPLICABLE IN THE TREATMENT OF DERMATOSIS, PRURITO, EDEMAS, ERITEMAS. *FORMULA* (Machine-translation by Google Translate, not legally binding)