TC99M-PHENIDA, RADIOSCINTIGRAPHIC AGENT FOR DIAGNOSIS OF HEPATOBILIARY DISEASE

摘要

16757TITLE OF THE INVENTIONTc99m-PHENIDA, RADIOSCINTIGRAPHIC AGENT FOR DIAGNOSISOF HEPATOBILIARY DISEASEABSTRACT OF THE DISCLOSUREThis invention relates to novel derivativesof imino diacetic acid of the formula:wherein R1 is selected from the group consisting of:- 2 - 16757wherein X is halo (chloro, bromo or iodo) and R2 islower alkyl of from 1-5 carbon atoms. It alsorelates to a novel diagnostic kit for heptaobiliaryimaging comprising ingredients employed in theintravenous injection of a complex of technetium 99m,and an imino diacetic acid of the above formula. Italso relates to a Process for preparing saidcompounds by reaction of nitrilotriacetic acidanhydride and an amine of the formula R1NH2wherein R1 is as defined hereinabove.