10-(SUBSTITUTED PHENYL)-3-ALKYLFLAVIN DERIVATIVES HAVING ANTIPROTOZOAL, ANTIPROLIFERATIVE AND ANTIINFLAMMATORY ACTIVITY

摘要

Compounds of general Formula (I), wherein Y is selected from alkyl, alkenyl, alkynyl, phenylalkyl or substituted or unsubstituted phenyl; n is an integer from 1 to 5; R?1, R2, R3, R4¿ and X, which may be the same or different, are selected from -Y, -O-Y, -S-Y (wherein Y is as defined above or is unsubstituted or alkyl substituted cycloalkyl and cycloalkenyl), cyclic or non-cyclic amino moieties, halogeno, hydroxyl, thiol or cyano. The 5 N-oxide, dihydro and tetrahydro derivatives are disclosed. Preparation of the above compounds, compositions including the above compounds and methods of using such compositions for antiprotozoal, antiproliferative and/or antiinflammatory treatment of a human or animal are disclosed.