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Improvement in the process for preparing biaryl compounds via coupling of an arylamine with an arene
Improvement in the process for preparing biaryl compounds via coupling of an arylamine with an arene
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机译:通过芳基胺与芳烃偶联制备联芳基化合物的方法的改进
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摘要
Improvement in the process for preparing biaryl compounds via coupling of an arylamine with an arene in the presence of a nitrite, an acid and copper metal or a derivative thereof; the improvement is consisting in adding to the reaction mixture a trialkylorthoformate. The process may be used for preparing drugs such as Flurbiprofen and Xenbucin or intermediate compounds particularly useful for preparing Flurbiprofen, Flufenisal, Chlordimorin, Xenbucin, Xenysalate, Xenyhexenic acid and the like.
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