Recombinant DNA molecule; a process for producing human endothelial plasminogen activator inhibitor (PAI) or a mutant thereof; pharmaceutical composition; transformed host cells

摘要

The invention is based on succesfully cloning and expressing the human endothelial plasminogen activator inhibitor, PAI. The invention provides recombinant DNA comprising a DNA sequence coding for PAI or mutants thereof; a process for producing PAI or mutants thereof by culturing transformed host cells; pharmaceutical compositions comprising PAI or mutants thereof obtained therein; and transformed host cells capable of expressing PAI or mutants thereof.