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New pharmaceutical compositions for prolonged release tablets of an active principle and their method of preparation
New pharmaceutical compositions for prolonged release tablets of an active principle and their method of preparation
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机译:具有活性成分的缓释片剂的新药物组合物及其制备方法
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摘要
1. A composition for the preparation by extrusion of microparticles permitting a prolonged release of a biologically active substance, which composition consists of a biologically active substance, one or more non-hydrophilic polymers and from 10 to 40% by weight either of a mixture of at least two lipid excipients one of which has the property of dissolving or gelling the polymer or polymers and the other has lubricating properties or of a lipid excipient having both the property of dissolving or gelling the polymer or polymers and lubricating properties, and, if appropriate, one or more additives chosen from diluents and antistatic agents.
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