SUBSTITUTED AMIDO-CARBAMOYL PROSTAGLANDIN 7-OXABICYCLOHEPTANE ANALOGUES WITH THERAPEUTIC ACTION

摘要

P COMPOUNDS HAVING FOR FORMULA: BR/ (CF DRAWING IN BOPI) BR/ INCLUDING ALL THEIR STEREO-ISOMERS, FORMULA IN WHICH M IS A NUMBER OF 0 TO 4; EAST -CHCH- OR -CH-CH-; N IS A NUMBER OF 1 TO 5; R IS A RADICAL COH, COALKYL, ALKALINE CO-METAL, POLYHYDROXYAMINE CO-SALT, BR/ (CF BRAZING IN BOPI) BR/ OR A RADICAL OF CNRR FORMULA, IN WHICH R AND R ARE IDENTICAL OR DIFFERENT AND ARE A HYDROGENIC ATOM OR LOWER ALKYL RADICAL, HYDROXY, LOWER ALCOXY OR ARYLIC, AT LEAST ONE OF R AND R OTHER THAN THE HYDROXY GROUP AND THE LOWER ALCOXY RADICAL; P IS A NUMBER OF 1 TO 4; X IS O OR S; Q IS A NUMBER OF 1 TO 6; R IS HYDROGEN ATOM OR LOWER ALKYL RADICAL; AND R IS A LOWER ALKYL RADICAL, LOWER ALKENYL CONTAINING 2 TO 12 ATOMES OF CARBON, ARYL, ARYLALKYL, CYCLOALKYL OR CYCLOALKYLALKYL. These compounds are CARDIOVASCULAR AGENTS USEFUL, FOR EXAMPLE, IN THE TREATMENT OF THROMBOSES. / P