(2-5')-Oligo (3'-deoxyadenylate) and derivatives thereof

摘要

3'-deoxyadenosine 5'-triphosphate is oligomerized to form (2'- 5')- oligo (3'-deoxyadenylate) by incubation with adenosine triphosphate: (2'- 5')-oligo adenosine adenyl transferase, in the presence of an inert support carrying a double straded polynucleotide. The (2'-5')-oligo (3'- deoxyadenylate) is digested with a suitable phosphatase to remove the terminal phosphate groups. The thus produced corresponding 3'- deoxyadenosine compound is an anti-viral material effective against Herpes Simplex infection and effective in inhibiting the transformation of cells infected with Epstein Barr virus.