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21-leucine! human urogastrone, corresponding gene, corresponding recombinant plasmid, transformed cell and process for production thereof
21-leucine! human urogastrone, corresponding gene, corresponding recombinant plasmid, transformed cell and process for production thereof
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机译:21-亮氨酸!人尿苷,相应基因,相应重组质粒,转化细胞及其生产方法
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摘要
21-Leucine! human urogastrone, hUG, comprising a polypeptide represented by the specified amino acid sequence has been found to be equivalent to the known hUG which has 21-Met and is disclosed together with its syntheses. Double-stranded polydeoxyribonucleotides comprising a structural gene for expressing the hUG, a recombinant plasmid comprising a structural gene for expressing the hUG, and E. coli transformed by the recombinant plasmid are also disclosed. Thanks to the substitution of Met in the known hUG by Leu, the peptide of hUG can now be produced by a conventional or typical method in which a genetically engineered precursor fused polypeptide is cleaved by cyanogen bromide at Met in the fused polypeptide.
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