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Method for the synthesis of pharmacologically active compounds and intermediates for such synthesis
Method for the synthesis of pharmacologically active compounds and intermediates for such synthesis
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机译:合成药理活性化合物的方法和用于该合成的中间体
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摘要
A process for the preparation of an aryloxypropanolamine of the formula ##EQU1## wherein Ar is a carbocyclic or heterocyclic aromatic group and R is an alkyl or substituted alkyl group having 1 to 6 carbon atoms, characterized in subjecting a compound of the formula ##STR1## to oxidative cleavage to a dialdehyde of the formula ##STR2## which is then made subject to reduction, amination, acetal hydrolysis, and, where required, removal of a nitrogen protective group, to the formation of a compound of formula I, or an acid addition salt thereof, a compound of formula II and the preparation thereof from mannitol.
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