Temperature correlated force and structure development of elastin polytetrapeptides and polypentapeptides

摘要

A bioelastomer containing elastomeric units comprising tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues, wherein said repeating units exist in a conformation having a &bgr;-turn which comprises a polypentapeptide unit of the formula: ##EQU1## wherein I is a peptide- forming residue of L-isoleucine; PPP is a peptide-forming residue of L-proline;P PG is a peptide-forming residue of glycine;PPV is a peptide-forming residue of L-valine; andPPwherein X.sup. 1 is PGVG, GVG, VG, G or a covalent bond; Y.sup.1 is IPGV, IPG, IP, I or a covalent bond; and n is an integer from 1 to 200, or n is 0, with the proviso that X.sup.1 and Y.sup.1 together constitute at least one of said pentameric unit, in an amount sufficient to adjust the development of elastomeric force of the bioelastomer to a predetermined temperature.