1-ACYL-2,3-DIHYDRO-4(1H)-QUINOLINE-4-OXIME DERIVATIVE, PRODUCTION THEREOF AND DIURETIC, ANTIHYPERTENSIVE, ANTIEDEMIC AND ABDOMINAL DROPSY REMOVING MEDICINE COMPOSITION CONTAINING SAID DERIVATIVE AS MAIN INGREDIENT

摘要

NEW MATERIAL:1-Acyl-7-halo-2,3-dihydro-4(1H)-quinoline-4-oxime-O-sulfonic acid derivative expressed by formula I [R1 is an aromatic group which may have substituent groups; X is halogen; wavy line represents syn or anti type bond], salt thereof and solvated product thereof. EXAMPLE:7-Chloro-2,3-dihydro-1-(2-dimethylaminobenzoyl)-4(1H)-quinolin e-4-oxime- O-potassium sulfonate. USE:A medicine having strong antihypertensive, antiedemic, diuretic and abdominal dropsy-removing action. PREPARATION:A compound expressed by formula II is reacted with hydroxylamine-O-sulfonic acid in the presence of an organic base such as pyridine, N.N-dimethylaniline or potassium acetate or inorganic base such as potassium carbonate or sodium carbonate to provide the compound expressed by formula I, salt thereof and solvated product thereof.