ORIGOMER OF 3-HYDROXYBUTANIC ACID, ESTER OF SAID ACID AND PHARMACEUTICAL COMPOSITION OF DERIVATIVE OF HYDROXYBUTANIC ACID SELECTED FROM ESTER OF SAID OLIGOMER AND 3-BUTANEDIOL

摘要

PURPOSE: To prepare a pharmaceutical composition, containing a derivative of 3-hydroxybutanoic acid and useful for purifying blood, especially purifying the blood of a dialytic solution for renal insufficiency. CONSTITUTION: This pharmaceutical composition contains a derivative of 3- hydroxybutanoic acid selected from among an oligomer of the 3-hydroxybutanoic acid and an ester of the acid or an ester of the oligomer with 1,3-butanediol, as an active ingredient, and is prepared according to a conventional method. The oligomer of the 3-hydroxybutanoic acid is composed of a dimer and/or a trimer or has the dimer and/or trimer with a high content. The 1,3-diol contained in the ester may be various isomers of the L-, D- or racemic form. The derivative concentration of the 3-hydroxybutanoic acid is 0.5-200g based on 1L dialytic solution.