SYNTHESIS OF N-ISOPROPYL-N'-O- CARBOMETHOXYPHENYL SULFAMIDE

摘要

In order to synthesize N-isopropyl-N'-o-carbomethoxyphenylsulphamide, sulphuric chlorohydrin is reacted with a pyridic base between -10 DEG and 50 DEG C., after which anthranilic acid methyl ester is firstly added at 0 DEG -60 DEG C., followed by isopropylamine at 0 DEG -60 DEG C., and finally phosphoric anhydride at 20 DEG -80 DEG C., the product being precipitated by dilution with water and recovered by filtration.