NOVEL N6,N6-DIMETHYLADENOSINE DERIVATIVE HAVING CARCINOSTATIC ACTIVITY, ITS PRODUCTION AND CARCINOSTATIC AGENT CONTAINING SAID DERIVATIVE AS ACTIVE COMPONENT

摘要

NEW MATERIAL:The N6,N6-dimethyladenosine sugar ester derivative of formula I (R is =4C alkyl =2C halogenated alkyl, =4C alkyl having 1,2-dithiolane ring at the terminal, =4C alkenyl or alkynyl) or its isopropylidene derivative at 2,3-sites of the sugar part. USE:A carcinostatic agent. PREPARATION:2',3'-0-isopropylidene-N6,N6-dimethyladenosine of formula II is made to react with carboxylic acids or carboxylic acid halides of formula III (X is OH or halogen) and, as necessary, removing the isopropylidene group by acid hydrolysis.