METHOD OF ANALOGUE FOR THE PREPARATION OF N-PHENYLETHANOLAMINOALKYL-SUBSTITUTED NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS OR ACID ADDITION SALTS.

摘要

Compounds of the formula IMAGE wherein Het is IMAGE IMAGE +TR IMAGE n is an integer from 1 to 4, inclusive, preferably 2 or 3, R1 is H or acyl, R2 is H, R1O, -NHSO2R7, -NHCOR8, -NHCONHR8, -NH-CH2-C6H4-R9, -CH2OH, -CH2SO2R7, -CONHR8, halogen or -CN, R3 is H, halogen, R7 or -OR7, R2 and R3 together with each other are IMAGE R4 is H, -CH3 or -C2H5, R5 and R6 are each H or -CH3, R7 is C1-C4 alkyl, R8 is H or C1-C4 alkyl, R9 is H, C1-C4 alkyl or C1-C4 alkoxy optionally interrupted by oxygen, R10 and R12 are each H, CH3, Cl or OCH3, or together methylenedioxy, X is IMAGE or N, and Z is -CH2 or -CO; in the form of racemates, enantiomers, diastereoisomeric antipode pairs, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as bronchospasmolytics, spasmolytics, muscle-relaxants, antiallergics and hypotensives.