3r,s and the 3r forms of 3 - substuerede 1 - (2 - aryl - or heteroarylethyl) piperidine compounds and their use for the manufacture of a medicinal product for the treatment of with associated with amended motipoints and / or tone of glatmuskel and pharmaceutical preparations containing these compounds

摘要

The (3R,S)- or (3R)- form of a compound of the formula:- CHEM or a pharmaceutically acceptable salt thereof, wherein R1 is a group of the formula:- CHEM where each Y, which may be the same or different, is selected from the substituents hydrogen, halo and C1-C4 alkyl: X is -(CH2)2-, -CH=CH-, -CH2-S-, -CH2-O-, -S- or -O-; and R is a group of the formula:- CHEM wherein R2, R3, R4 and R5 are certain specified substituents. The compounds are useful in the treatment of diseases associated with altered motility and/or tone of smooth muscle.