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procedure for the manufacture of tertiaere karbinoler containing a aminisk substituent
procedure for the manufacture of tertiaere karbinoler containing a aminisk substituent
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机译:含有明锐取代基的叔丁醇二甲醚的制备方法
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摘要
A process for the preparation of tertiary diphenyl carbinols containing a primary or secondary amine substituent on the aliphatic moiety attached to the carbinol function which consists in contacting a Grignard phenyl reagent with an aminoacid wherein the mobile protons are not masked in an aprotic inert organic solvent or a mixture thereof at a temperature between 20 DEG C and the boiling temperature by the reaction mixture. The reaction products are useful as active ingredients of medicaments and intermediates for the manufacture thereof.
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