aids laekemedel baserade pao hiv proteasinhibitorer.

摘要

A therapeutic active compound, especially for treating AIDS, comprising (A min )k-(Z)n-(Y)m-A sec wherein A min is CHEM or hydrogen, wherein R1 is OR2, NR3R2 or CR2R3R4, R2,R3 and R4 are, independent of each other, hydrogen, an aliphatic or an aromatic, wherein k is one or zero, wherein when Z is hydrogen, k is zero, Z is hydrogen, Ser or Thr or R1 - @, wherein n is one or zero, with the proviso that when Y is hydrogen, n is zero, Y is hydrogen or R1 - @, or CHEM wherein R9 is hydrogen or an aliphatic or aromatic, wherein m is one or zero, wherein when E4 is hydrogen, m is zero, A sec is CHEM wherein E4 is hydrogen or Asn or R1- @, wherein CHEM is a 4 to 7 membered ring system, wherein only Q, Q min , Q sec may be different from carbon, wherein the substituent is an aliphatic or aromatic, wherein E1 is @; wherein E3 is CHEM wherein E2 is CHEM wherein E4 is hydrogen or Asn, or CHEM but if E2 is R5 CHEM E4 is not R2-O- @- , wherein R5 is an aromatic or aliphatic, wherein X is hydrogen or R1 or CHEM wherein R6 is an aliphatic, wherein R10 is hydrogen or CHEM wherein A2 has the formula CHEM