PROCESS FOR PRODUCING SPIRO SQUARE BRACKETS OPEN IMIDAZOLIDINE-4,5'(6H)-QUINOLINE SQUARE BRACKETS CLOSED-2,5-DIONE DERIVATIVES

摘要

Spiro-heteroazolone compounds of the formula: CHEM or a pharmaceutically acceptable salt thereof, wherein A is methylene, hydroxymethylene, or methine; Y is methylene, alkylmethylene, methine or alkylmethine, wherein alkyl in each instance has 1-4 carbon atoms; with the proviso that when A is methine, Y is methine or alkylmethine; Z is oxygen, sulfur, or nitrogen substituted by hydrogen; O is nitrogen or nitrogen-N-oxide; and X is in the 3 min -position and is hydrogen, halo, alkyl, alkoxy having 1-4 carbon atoms, alkylthio, alkylsulfinyl, alkylsulfonyl, phenoxy, phenylthio, or nitro; or X is in the 2 min -position and is hydrogen, alkyl, or alkoxy having 1-4 carbon atoms; wherein alkyl in each instance has 1-4 carbon atoms; with the proviso that when O is nitrogen-N-oxide, X is not alkylthio, alkylsulfinyl or phenylthio; and with the further proviso that when O is nitrogen and X is hydrogen and Z is nitrogen subsitituted by hydrogen, at least one of A and Y is always other than methylene. The compounds have utility as aldose reductase inhibitors and as therapeutic agents for the treatment of complications arising from diabetes.