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ACTIVE AGENTS CONTAINING HYDROGEL DEVICES WHEREIN THE ACTIVE AGENT CONCENTRATION PROFILE CONTAINS A SIGMOIDAL CONCENTRATION GRADIENT,FOR IMPROVED CONTROLLED RELEASE,THEIR MANUFACTURE AND THEIR USE
ACTIVE AGENTS CONTAINING HYDROGEL DEVICES WHEREIN THE ACTIVE AGENT CONCENTRATION PROFILE CONTAINS A SIGMOIDAL CONCENTRATION GRADIENT,FOR IMPROVED CONTROLLED RELEASE,THEIR MANUFACTURE AND THEIR USE
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机译:活性剂浓度曲线中包含水凝胶装置的活性剂包含西格玛浓度梯度,用于改进的控制释放,其制造和使用
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摘要
An active agent containing controlled release diffusion device comprising a swellable hydrogel matrix in the non-swollen state, interpenetrated with an active agent solute having a stable concentration distribution increasing in a gradient normal to the surface of the device and between the surface and the core thereof, said gradient being in the form of a substantially continuous, inflection point containing, sigmoidal curve, such that the device, when placed in an aqueous hydrogel swelling environment, releases said active agent in a controlled continuous manner by diffusion for a predetermined period of time, a method of preparing such a device, and the use thereof to release an active agent into the intended environment of use.
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