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7ALPHA-ALKANOYLTHIO-9ALPHA-,11ALPHAEPOXY STEROIDS OF THE 20-SPIROXANE SERIES,THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
7ALPHA-ALKANOYLTHIO-9ALPHA-,11ALPHAEPOXY STEROIDS OF THE 20-SPIROXANE SERIES,THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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机译:20-螺氧烷系列的7α-链烷烃基thio-9α-环氧烷烃,其制备方法及组成
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摘要
7 alpha -acylthio-9 alpha ,11 alpha -epoxy-20-spirox-4-ene-3,21-diones of the formula I IMAGE (I) in which R represents lower alkanoyl and -A-A- represents an ethylene or cyclopropylene group, have a high aldosterone-antagonistic activity without significant sexually-specific side-effects and can be used as potassium-protecting diuretics in the treatment of various forms of hyperaldosteronism. The compounds can be obtained by conventional processes of steroid chemistry.
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