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EXPRESSION VECTORS FOR EGLIN B OR C (PROTEASE INHIBITORS), TRANSFORMED HOST, PREPARATION, MODIFIED EGLINS AND COMPOSITIONS
EXPRESSION VECTORS FOR EGLIN B OR C (PROTEASE INHIBITORS), TRANSFORMED HOST, PREPARATION, MODIFIED EGLINS AND COMPOSITIONS
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机译:EGLIN B或C的表达载体(蛋白酶抑制剂),转化的宿主,制备,修饰的胶体和成分
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1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE An eglin compound of the formula VGluPheGlySerGluLeuLysSerPhePro GluValValGlyLysThrValAspGlnAlaArgGlu TyrPheThrLeuHisTyrProGlnTyrAspVal WPheLeuProGluGlySerProValThrLeuAsp LeuArgTyrAsnArgValArgValPheTyr AsnProGlyThrAsnValValAsnHisValProHis ValGly in which V is N-acetyl-Thr and W is Tyr or His, and a pharmaceutically acceptable salt thereof. 1. Claims for the Contracting State : AT A process for the preparation of N**alpha -acetyl-eglin B, N**alpha -acetyl-eglin C and a salt thereof which comprises culturing an Escherichia coli or Saccharomyces cerevisiae strain which has been transformed with a DNA vector containing a DNA sequence coded for eglin B or eglin C and suitable for expression in E. coli or S. cerevisiae, in a liquid nutrient medium containing assimilatable sources of carbon and nitrogen, releasing the product from the host cells and isolating it, and, if desired, converting a resulting salt into the free polypeptide and converting a resulting polypeptide into a salt thereof.
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