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PROCESS FOR OBTAINING GENETICALLY STABLE NONTOXIGENEOUS FORM OF VIBRIO CHOLERAE SPECIES
PROCESS FOR OBTAINING GENETICALLY STABLE NONTOXIGENEOUS FORM OF VIBRIO CHOLERAE SPECIES
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机译:获得弧菌霍乱弧菌的遗传稳定的非毒素形式的方法
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摘要
Plasmids and modified strains of Vibrio cholerae are prepared which are a genetically stable nontoxinogenic form of Vibrio cholerae which has a deletion mutation in both copies of the A1-peptide-encoding gene, resulting in the loss of a gene sequence required for expression of a toxic A1 peptide. The modified strains are useful as live or dead oral vaccines.
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