13 - oxaprostaglandiner of pge type, saett to framstaella thereof and a pharmaceutical composition

摘要

Prostaglandin analogues of formula (I) are new: n = 1 or 2; m = 2-5 and X = cis. or trans-CH=CH or CH2CH2, or m = 1-4 and X CH=C=CH; R1 = (a) phenyl opt. substd. by 1-4C alkyl, 1-4C alkoxy, 1-4C alkanoyl, SMe, SOMe, SO2Me, halogen, COOR2, NHCOR'2, CONR3R4, NHCONH2, CH2CH(CONH2)NHCOMe or 2-benzamido-2 -carbamoylethyl, or (b) 2-naphthyl; R2 = H, 1-4C alkyl, phenyl or a cation; R'2 = H, 1-4C alkyl or phenyl opt. substd. by OH, NHCOMe or benzamido; R3 and R4 = H or 1-4C alkyl; Y = CH2-CR5(OH)-CR6(OAr)-R7; R5-R7 = H or Me, at least one being H; Ar = phenyl opt. substd. by 1 or 2 of 1-4C alkyl, 1-4C alkoxy, 1-4C alkylthio, 1-4C alkylsulphinyl, 1-4C alkylsulphonyl, halogen and CF3. - (IR-(1alpha(Z), 2beta(R), 3alpha))-(-) -4-benzamidophenyl 7-(3-hydroxy-2-(2 -hydroxy-3-phenoxypropoxy) -5-oxocyclopentyl) -5-heptenoate (Ia) is specifically claimed.