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antibiotic cephalosporinderivate, methods for their manufacture and pharmaceutical praeparate.
antibiotic cephalosporinderivate, methods for their manufacture and pharmaceutical praeparate.
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机译:头孢类抗生素抗生素,其制造方法和普雷帕特药物。
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摘要
The compounds according to the invention correspond to the formula: IMAGE (I) in which: The COOA group at the 4 position is an acid radical, or an alkaline or alkaline-earth salt, or an amino acid or amine salt, for example triethylamine or ethanolamines, or an easily hydrolyzable or metabolically labile and pharmaceutically acceptable ester radical. X denotes an oxygen atom or a sulfur atom n is zero or 1 R1 and R2 each denote independently hydrogen or a lower alkyl group, preferably a methyl group, or R1 and R2 taken together with the carbon atom to which they are linked form a cyclobutyl or cyclopentyl nucleus. B is the residue of a primary or secondary amine.
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机译:根据本发明的化合物对应于式:<图像>(I)其中:在4位的COOA基团是酸基,或者是碱金属或碱土金属盐,或者是氨基酸或胺盐。例如三乙胺或乙醇胺,或易水解或代谢不稳定且药学上可接受的酯基。 X表示氧原子或硫原子,n为零或1 R 1和R 2各自独立地表示氢或低级烷基,优选甲基,或R 1和R 2与它们所连接的碳原子一起形成环丁基或环戊基核。 B是伯胺或仲胺的残基。
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