RADIOACTIVE DIAGNOSTIC AGENT, AND NON-RADIOACTIVE CARRIERS THEREFOR

摘要

-1-Abstract:The invention provides a radioactive diagnosticagent which comprises (1) a unit of a polyformyl compoundhaving at least three formyl groups per molecule, (2) atleast two units of an amino group-containing chelatingcompound bonded to the polyformyl compound via a methyl-eneimine linkage (-CH=N-) or a methyleneamine linkage(-CH2NH-) formed by the condensation between a formylgroup in the polyformyl compound and the amino group inthe chelating compound, optionally followed by reduction,(3) at least one unit of an amino group-containing phys-iologically active substance bonded to the polyformylcompound via a methyleneimine linkage or a methyleneaminelinkage formed by the condensation between a formyl groupin the polyformyl compound and the amino group in thephysiologically active substance, optionally followedby reduction, and (4) at least two radioactive metallicelements of which each is bonded to the chelating compoundthrough a chelating bond. The diagnostic agent can beused for non-invading nuclear medical diagnosis.