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Galenical insulin forms for per- and sublingual administration
Galenical insulin forms for per- and sublingual administration
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机译:Galenical胰岛素形式用于舌下和舌下给药
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摘要
Insulin, in "rapid", "semi-retard" or "retard" form, is contained in strictly controlled and reproducible amounts in solid vehicles contrived for a gradual release of the active principle per- and sublingually. The process for preparing these new pharmaceutical dosage forms entails the following steps: - dissolution of insulin in a polar solvent to obtain a stock solution; - preparation of dilutions at different concentrations; - fractionation of each of these dilutions into subdilutions; - impregnation by multi-impregnation or fractional impregnation of a pharmaceutically acceptable solid vehicle with each of the subdilutions, each of the abovementioned impregnation steps being followed by a forced-air drying with moisture-free air at a temperature not exceeding 30 DEG C; - protective final impregnation of the sugar-coating type.
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