ASYMMETRIC HYDROFORMYLATIONS OF PROCHIRAL OLEFINS TO CHIRAL ALDEHYDES IN HIGH ENANTIOMERIC EXCESS

摘要

Asymmetric hydroformylation of chiral olefins can be obtained by contacting, under hydroformylation conditions, an olefin containing a prochiral center with hydrogen and carbon monoxide in the presence of a catalyst comprising a complex platinum II and N- (t-butoxycarbonyl) -2S, 4S) -4- (diphenylphosphino) -2 - [(diphenylphosphino) methyl] pyrrolidine and stannous chloride, and extracting the resulting chiral aldehyde as it forms. A preferred method the resulting chiral aldehyde of extraction consists in using a prison agent such as triethyl orthoformate, a trimethyl orthoformate, triethyl orthoacetate, trimethyl orthoacetate a, a diethyl ketal of acetone and a dimethyl acetal of acetone used in the presence of a catalyst carrier in the solid state such as a crosslinked polystyrene.