Nucleic acid probes with non-radioactive labels, and preparation processes

摘要

The invention relates to a nucleic acid probe containing a nucleic acid sequence, wherein this sequence is linked at its 5' end via a divalent bifunctional chemical "arm" L to a "labelling component" M, M being a synthetic or natural molecule detectable directly or indirectly on a non-isotopic basis, according to the formula I: …IMAGE… in which… J = H or OH… n represents the number of nucleotides from 1 to 100,000… B = a purine or pyrimidine nucleic acid base which varies, as appropriate, according to the nucleotides.