Desazapulin-nucleoside derivatives, methods for their preparation, pharmaceutical compositions containing them, their use for hexane configuration and their use as antiviral agents

摘要

Novel deazapurine nucleosides of the formula I IMAGE in which X denotes nitrogen or a methine group, W denotes nitrogen or the group IMAGE R1, R2, R3 and R4 can be the same or different, and denote hydrogen, halogen, a lower alkyl, hydroxyl, mercapto, lower alkylthio, lower alkyloxy, aralkyl, aralkyloxy, aryloxy or an optionally mono- or disubstituted amino group, R5 denotes hydrogen or a hydroxyl group, R6 and R7 each denote hydrogen or one of the two radicals R6 and R7 denotes halogen, a cyano, azido or an optionally mono- or disubstituted amino group, where one of the radicals R6 and R7 can also represent a hydroxyl group if X denotes a methine group, and R5 and R7 together can additionally represent a further bond between C-2' and C-3' and Y represents hydrogen, a monophosphate, diphosphate or triphosphate group, and possible tautomers and salts and nucleic acids which contain one or more compounds of the formula I as building block. The compounds according to the invention exhibit antiviral properties and can further be used in DNA sequencing, where they lead to chain termination and/or prevent band compression.