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7-/ D (-)-alpha-amino-alpha-(p-hydroxyphenyl) acetamido / 3-(1,2,3-Preparation of 4-carboxylic acid 1,2-propylene glycolate and intermediates for halogenated processes
7-/ D (-)-alpha-amino-alpha-(p-hydroxyphenyl) acetamido / 3-(1,2,3-Preparation of 4-carboxylic acid 1,2-propylene glycolate and intermediates for halogenated processes
Cefatrizine 1,2-propylene glycolate is prepared by reacting p-hydroxyphenylglycine chloride hydrochloride with 7-amino-3-iodomethyl-3-cephem-4-carboxylic acid, and then reacting the thus obtained novel intermediate, 7-[D(-)- alpha -amino- alpha -(p-hydroxyphenyl)-acetamido]-3-iodomethyl-3-cephem-4-carboxylic acid, with the sodium salt of 1,2,3-triazol-4(5)-thiol in 1,2-propylene glycol. The addition of water to the reaction mixture causes the cefatrizine, 1,2-propylene glycolate to precipate.
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