METHOD OF PRODUCING (4,2,0)BICYCLOOCTANE DERIVATIVES OF THEIR PHARMACEUTICALLY ACCEPTABLE NON-TOXIC SALTS OR PHARMACEUTICALLY ACCEPTABLE NON-TOXIC ESTERS

摘要

Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension, and atherosclerosis are compounds depicted in formulas (1), (2), and (3): IMAGE (1) IMAGE (2) IMAGE (3) wherein: n is 2 or 3; R1 is CH2OH, CHO, CO2R or CO2H; R2 is hydrogen or methyl; and R3 is linear or branched alkyl having 5-10 carbon atoms, IMAGE +TR or (CH2)mphenyl optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen, in which a is 0, 1 or 2; b is 3-7; m is 1 or 2; and R is IMAGE +TR IMAGE in which each R4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, and the pharmaceutically acceptable, non-toxic salts and esters thereof.