METHOD FOR PRODUCING ITACONIC ACID DIESTERS AND ITACONIC ACIDS

摘要

1,1-Disubstituted ethylene compounds of the formula I …IMAGE… in which… Z is COOR2, CN or COR3,… R1 denotes an aliphatic, cycloaliphatic, araliphatic, aromatic or heterocyclic radical which may optionally be further substituted by functional groups which are inert under the reaction conditions,… R2 denotes an aliphatic, cycloaliphatic or araliphatic radical having 1 to 15 carbon atoms and… R3 denotes an aliphatic, cycloaliphatic or araliphatic radical having 1 to 15 carbon atoms which may be substituted by groups which are inert under the reaction conditions, it being however also possible for R1 together with R2 or R1 together with R3 to form an alkylene chain having 2 to 10 carbon atoms, which may be substituted by groups which are inert under the reaction conditions, are prepared from formyl compounds of the formula II …IMAGE… in which Z, R1, R2 and R3 have the abovementioned meanings, the reaction being carried out in the presence of formaldehyde or paraformaldehyde and… a) a C1-C12-alkanol or… b) a mixture of a C1-C12-alkanol and water or… c) using water in the presence of a secondary amine and a protic acid at temperatures of 0 to 200 DEG C.