Esters and amides of indole-, benzobthiophene or benzobfurancarboxylic acids or 4-amino-2-methoxybenzoic acids with N-heterocyclic or N-heterobicyclic alcohols or amines, processes for their preparation, pharmaceutical compositions containing them and applicator for administration thereof

摘要

Compounds of the formula A-CO-B-D in which A, B and D possess the meaning indicated in Claim 1, processes for their preparation, and pharmaceutical compositions containing them having action against pain, in particular for the treatment of migraine, as antiarrhythmics and for the treatment of gastrointestinal disorders such as gastric secretion disorders, gastritis, peptic ulcer, dyskinesia of the bile tracts, spastic colon, irritable colon, Crohn's disease, ulcerative colitis, carcinoid syndrome and diarrhoea of varying origin (e.g. bacterial diarrhoeas, cholangenic diarrhoea, psychogenic diarrhoea) and for the improvement of gastric emptying, for the treatment of gastroduodenal and gastrooesophageal reflux, of oesophageal motility disorders, achalasia, hiatus hernias, cardiac insufficiency, hypotonia of the stomach, pylorus hyperplasia, paralytic ileus and Hirschsprung's disease, and also for the treatment of anxiety states, of psychiatric disorders such as social withdrawal phenomena, manic-depressive psychoses, psychoses and other illnesses connected with stress, disorders of the state of alertness such as geriatric syndromes, and also for the treatment of rhinitis, pulmonary embolism and for the improvement of the nasal absorption of other active compounds, e.g. of peptides, and the inhibition of emesis caused by cytostatics.