NOVEL PLASMODIUM FALCIPARUM PROTEASE, ANTIBODIES THEREFOR, PEPTIDE SUBSTRATES SPECIFIC TO SAID PROTEASE, AND THEIR USE AS A MEDICINE AGAINST MALARIA

摘要

Utilization as active ingredients in the preparation of a drug against paludism of compounds having formula (I): R1-P1-P2-R2, wherein P1 is in particular a peptidic rest selected amongst TLG, IVG, VLG and SG, or N-methylated analogs thereof or having a D configuration, R1 is particularly H, a protection group for the N-terminal group, or a hydrosolubilizing group, P2 is for example a rest of lysin or arginine, or R2 is particularly -OH, -CH2Cl, the rest of an aliphatic amine, or the rest of an aminated antipaludic drug, it being understood that in the compounds of formula (I), the peptidic bond between at least two acids of the rest P1 and/or between P1 and P2, and/or optionnaly between P1 et R1 and/or between P2 et R2 may be replaced by a pseudo-peptidic bond.