ANTIMICROBIAL PHARMACEUTICAL COMPOSITIONS BASED ON A SYNERGISTIC COMBINATION FOR TOPICAL APPLICATION AND PROCESS FOR THEIR PREPARATION

摘要

These pharmaceutical compositions for topical application contain a combination of an antimicrobial active substance containing in the molecule an imidazole ring substituted by a lower alkyl group, namely a compound of formula I: BR/ (CF DRAWING IN BOPI) BR / in which at least one of the symbols R1, R2 and R3 represents a halogen atom and the others hydrogen, or a compound of formula II: BR/ (CF DRAWING IN BOPI) BR / in which R4 represents a halogen, and one or more optionally substituted benzoic acids. /P P These compositions are distinguished by a strongly synergistic antimicrobial activity.