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Method for the preparation of granulates suited for the production of sustained release coated tablets for oral use
Method for the preparation of granulates suited for the production of sustained release coated tablets for oral use
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机译:制备适合生产用于口服的持续释放包衣片剂的颗粒的方法
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摘要
A method for the preparation of tablets slowly releasing the active principle, characterized in that (I) during the granulation step a solution in organic solvents of a polymer insoluble in biological juices is sprayed on a mixture containing an active principle, slightly swelling polymers and usual excipients; (II) the granulated obtained in this way is added with a highly hydroswelling colloidal polymer; (III) a solution, in organic solvents, of an entero-soluble polymer, is sprayed on the granulate; (IV) the resulting granulate is submitted to compression; (V) the obtained tablets are hardened by washing with organic solvents; and (VI) they are then optionally coated.
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