Method to detect T-antigen delayed hypersensitivity

摘要

Processes are provided for the synthesis of the human T- antigenic determinant 2-acetamido-2-deoxy-3-O-(&bgr;-D-galactopyranosyl)- &agr;-D- galactopyrano side containing an &agr;-O-glycosidically linked bridging arm O--(CH.sub.2).sub.n COR. The determinant is coupled to carrier molecules to form artificial T-antigens, and to insoluble supports to form T-immunoadsorbents. The artificial T-antigen is shown to elicit a delayed type hypersensitivity reaction as a diagnostic for the presence of cancer in humans.