NEW MATERIAL:A prostaglandin I shown by formula I or formula II (R1 is H or alkyl; R2 and R'2 are each independently H, halogen, alkyl, aromatic group-containing group, hydroxyl group or alkoxy with the proviso that a case where R2 and R'2 are H at the same time is omitted) or a salt thereof. EXAMPLE:13,14-Dihydro-15-keto-16(RS)-fluoro-9(O)-methanol- 6(9alpha) PGI1 methyl ester. USE:Useful as an antihypertensive agent effective for alleviating other pharmaceutical and physiological action such as increase in pulse rate. PREPARATION:For example, a compound shown by formula III is reacted with an ylide prepared from (3-carboxypropyl)triphenylphosphine bromide and potassium t-butoxide, further with diazomethane to give a compound shown by formula IV. Then the compound is desilylated, subjected to Collins' oxidation, reacted with a specific anion and further reduced to give an ester derivative of a compound shown by formula I.
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