SELECTIVE ABSORBENT TO TNF, AND SEPARATION AND REMOVAL OF TNF IN PLASMA

摘要

PURPOSE:To selectively separate and remove a tumor necrosis factor (TNF) from human plasma by forming a selective adsorbent to TNF by bonding Tamm-Horsfall protein to an insoluble carrier. CONSTITUTION:Tamm-Horsfall protein (THP) is bonded to at least one insoluble carrier selected from a group consisting of cephalose, polyacrylamide, cellulose, dextran and polymaleic acid to form a selective adsorbent to TFN. Plasma containing a human TFN is brought into contact with the selective adsorbent obtained by bonding THP to the insoluble carrier as mentioned above to separate and remove the human TNF from the plasma containing the human TNF. The aforementioned insoluble carrier can be formed into various shape such as a powder, a granule, a pellet, a bead, a film or a fiber.