COMBINATION OF ANGIOTENSIN INVERTASE INHIBITOR AND POTASSIUM CHANNEL MODULATOR

摘要

PURPOSE: To obtain a medicine useful for curing hypertension, cardiac failures and coronary artery heat diseases by combining an angiotensin conversion enzyme(ACE) inhibitor with a potassium channel modulator. CONSTITUTION: This combination product an ACE inhibitor with a potassium channel modulator is a medicine consisting of a combination of (A) a compound expressed by formula I [(n) is 1 or 2; R is H, a 1-8C aliphatic group, a 3-9C alicyclic group, a 6-12C aromatic group, etc.; R1 is a 1-6C aliphatic group, a 3-9C alicyclic group, a 2-12C aromatic group, etc., R2 and R3 are each H, a 1-6C aliphatic group, a 6-9C alicyclic group, a 6-12C aromatic group, etc.; R4 and R5 form a 5-15C heterobicyclic or heterotricyclic ring together with atoms to which they are bound), e.g. ramipril, quinapril, with (B) a potassium channel modulator, e.g. a compound expressed by formula II [R6 is CN, NO2 , an SOn -C1-6 alkyl [(n) is 1 or 2], etc.; R7 is H, OH, a 1-2C alkoxy, etc.; R8 and R9 are each a 1-4C alkyl; X is (CH2 )2-4 ], (e.g. chromakalium).