10 BETA, 11 BETA-CROSSLINKED STEROID, INTERMEDIATE, PRODUCTION THEREOF AND ANTI- GESTAGEN AND ANTI-GLUCOCORTICOIDE ATING DRUG CONTAINING THE SAME

摘要

10 beta ,11 beta -bridged steroids of Formula I IMAGE (I) wherein R1 is H or methyl; R2 is H, a cyanide residue, a heteroaryl residue, a straight-chain or branched aliphatic, e.g., alkyl group of up to 20 carbon atoms, optionally exhibiting double or triple bonds and, if desired, being substituted by one or several oxo groups, a C4-7 cycloalkyl or C4-7 cycloalkenyl group, an OR3-, SR3-, -OSO2-R11- group wherein R11 means a perfluroinated C1-C4-alkyl group or an NR3R4-group wherein R3 means an H atom or C1-C8-alkyl residue, R4 means R3, a cyanide or a C1-C10-acyl residue, or R3 and R4 jointly with the inclusion of N means of 5- or 6-membered heterocyclic ring wherein the ring can additionally contain a further hetero atom N, O, or S, or a 4-cyano-, 4-methoxy- or 4-dimethylamino-substituted phenyl group, A and B either mean jointly a further bond between C4 and C5, or A is an alpha -hydroxy group and B is H, X is a keto or oxime group, and Z is a pentagonal or hexagonal ring residue which is optionally substituted and optionally unsaturated, or pharmaceutically compatible acid additional salts thereof which possess antigestagen and antiglucocorticoid properties.