ANTIVRAL NONCYCLIC NUCLEOSIDE AND NONCYCLIC NUCLEOTIDE

摘要

Disclosed are compounds of the formula: CHEM wherein B is related to one of the heterocyclic bases found in nucleic acid (DNA, RNA) such as a purine, a substituted purine, a pyrimidine or a substituted pyrimidine wherein the substituents on the purine or pyrimidine are selected from amino, hydroxyl, halogen, thio or alkylthiol wherein the alkyl moiety of the alkylthiol has 1 to 6 carbons; R1 is fluorine, chlorine, hydroxy, alkoxy having 1 to 6 carbons or a phosphate group having the formula: CHEM wherein R4 and R5 are pharmaceutically acceptable cations; R2 and R3 are independently hydroxy, alkoxy having 1 to 6 carbons or a phosphate group having the formula: CHEM wherein R4 and R5 hydrogen or are pharmaceutically acceptable cations; or two of R1, R2 and R3 taken together form a phosphate group having the formula: CHEM wherein R4 is hydrogen or a pharmaceutically acceptable cation. The compounds have antiviral activity. They are particularly effective against the herpes group of viruses with special utility against cytomegalovirus (CMV) and varicella-zoster virus (VZV), and against retroviruses such as HTLV-III.