Jimechiruokutenjioorujudotaioyobisonoseizohoho

摘要

NEW MATERIAL:The compound of formula I [R1 and R2 are groups selected from the groups of (i) CH2R3, (ii) the group of formula II, (iii) the group of formula III and (iv) CH2SR10 provided that R1 and R2 are not in the same group; R3 is aryl; R4 and R5 are H or lower alkyl; 6 is lower alkyl, lower alkoxy-lower alkyl or together with R4 or R5 forms 4-5C alkylene; R7-R9 are lower alkyl or aryl; R10 is lower alkyl]. EXAMPLE:2-[8-Benzyloxy-2,6-dimethyl-2(Z)-octenyloxy]-tetrahydro-2H-pyran. USE:An intermediate of a carbon-chain extender for the synthesis of various isoprene compounds, especially a dolichol compound distributing widely in the body of mammals and playing an important role for the maintenance of life. PROCESS:The compound of formula I can be prepared by reacting the compound of formula IV (R11 is lower alkyl) with the Grignard reagent of formula V (X is halogen) in the presence of a copper salt.