A novel ligand specifically useful for radiotherapy or image processing of cancer and specific ligands for steroid hormone receptors

摘要

Compound useful particularly for the treatment by targetted radiotherapy or imaging of cancer, characterized in that the compound is comprised of a molecule susceptible of fixing itself or passing close to the DNA of the target cells, said molecule being radiolabelled with iodine 123. The invention also relates to new ligands specific of steroid hormone receivers useful for the targetted therapy or imaging particularly of cancer and presenting a structural base skeleton having the formula (I). According to the invention these ligands comprise particularly a) a hydroxyl or ketone function in position C3; b) a β chloromethyl function on position C11; c) an α methyl or vinyl function on position C17 and d) a substituted radioactive iodine on an alkyl or alkenyl group attached to the skeleton, particularly methyl or vinyl.